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Gray zone lymphoma is a rare type of lymphoma, cancer of a part of the immune system called the lymph system. It is called "gray zone" lymphoma because it has features intermediate between classical Hodgkin lymphoma and diffuse large B-cell lymphoma (DLBCL), but cannot be assigned specifically to either type. In many cases, the original diagnosis of gray zone lymphoma is later reclassified as a different type of lymphoma, such as nodular sclerosis classical Hodgkin lymphoma (NScHL). An accurate diagnosis of gray zone lymphoma is challenging, and the clinical characteristics, optimum therapy, and prognosis have not been well-defined. While some features suggest it should be treated like Hodgkin lymphoma, other features suggest it should be treated like DLBCL.
Source: GARD Last updated on 05-01-20
Gray zone lymphoma shares features with two other types of lymphoma, classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). Because these lymphomas are treated differently, the optimal therapy for gray zone lymphoma is unclear. Because there are no consensus guidelines for the best treatment of gray zone lymphoma, treatment is currently determined based on each individual's diagnosis. In general, treatment usually involves chemotherapy (with the specific drugs depending upon each person's treatment plan), which may be followed by radiation therapy in some cases. Some research has suggested that treatment with DLBCL- based regimens is the most effective for some people (such as the drug combination R-CHOP or dose-adjusted EPOCH-R), but additional research is needed. Individual case reports have reported success with different PD-1 inhibitors (such as pembrolizumab and nivolumab), but larger studies are needed to determine if this might be an effective new strategy for treating gray zone lymphoma.
Last updated on 05-01-20
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