AL amyloidosis

Are anomalies involving chromosomes 16 and X known to be associated with AL amyloidosis?

AL amyloidosis is frequently associated with chromosome anomalies. The anomalies that have been described in association with amyloidosis are numberous and varied. As a result, no single chromosome anomaly is characteristic for this condition.

One study did find an extra chromosome X (trisomy X) in 13% of women and 54% of men with systemic amyloidosis in their study population. We were not able to find a study which investigated the prevalence of chromosome 16 anomalies. One of the more common chromosome anomalies associated with systemic amyloidosis is a loss of a copy of chromosome 18 (i.e., chromosome 18 monosomy). In one study this anomaly was identifed in 72% of participants.

Last updated on 05-01-20

What are risk factors for AL amyloidosis?

The exact cause of AL amyloidosis is not known. The condition appears to occur in similar frequencies among people of various races. It is thought to occur more commonly in men than in women. AL amyloidosis is a disease of adulthood. The mean age of people at diagnosis of AL amyloidosis is 65 years. The condition results from an abnormality of plasma cells in the bone marrow. It is closely related to multiple myeloma.

You can visit the following link to the National Cancer Institute's Web site to learn more about risk factors for multiple myeloma.

Last updated on 05-01-20

Name: Amyloidosis Foundation 7151 N. Main Street Suite 2
Clarkston, MI, 48346, United States
Toll Free: 877-AMYLOID (1-877-269-5643) Email: Url:
Name: Amyloidosis Support Groups Inc. 232 Orchard Drive
Wood Dale, IL, 60191, United States
Phone: 630-350-7539 Toll Free: 866-404-7539 Email: Url:
Name: Amyloidosis Australia, Inc. 131-133 Napier Street St. Arnaud,
Victoria, 3478
Phone: 03 5495 1169 Email: Url:
Name: Amyloidosis Research Consortium 320 Nevada Street, Suite 210
Newton, MA, 02460, United States
Phone: 617-467-5170 Email: Url:

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