Gianotti Crosti syndrome

What causes Gianotti Crosti syndrome?

Gianotti Crosti syndrome (GCS) is thought to be due to a hypersensitive response to a previous infection. The underlying infection tends to correlate with the infectious agent endemic to a specific geographic region. For example, in Japan and Mediterranean countries, GCS is more commonly associated with hepatitis B virus infection. Since there is more universal use of hepatitis B immunization, Epstein-Barr virus is now the most common associated infection worldwide. GCS may also occur after coxsackievirus, infectious mononucleosis, cytomegalovirus, enterovirus infections, ECHO viruses, respiratory syncytial virus, or after vaccination with a live virus serum. In most cases, no laboratory tests are needed when a person is diagnosed with GCS. However, if jaundice or an enlarged liver are present, testing for hepatitis B and elevated liver enzymes may be performed.

The exact reasons for the cause and effect relationship between underlying infections and GCS are not well-understood. There does not appear to be any genetic or familial predisposition to developing GCS.

Last updated on 05-01-20


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