Fox-Fordyce disease

What is Fox-Fordyce disease?

Fox-Fordyce disease is a chronic skin disease most common in women aged 13-35 years. It is characterized by the development of intense itching in the underarm area, the pubic area, and around the nipple of the breast as a result of perspiration which becomes trapped in the sweat gland and surrounding areas. The cause is unknown, but heat, humidity, and stress may play a role. Treatment may include the use of retinoids, antibiotics, and immunosuppressants.

Last updated on 05-01-20

Are there over-the-counter medications which can help manage Fox-Fordyce disease?

After an extensive search of the resources currently available, there are no reports of over-the-counter medications which have been used to manage this condition. We recommend that you consult with a dermatologist for further information regarding treatment of Fox-Fordyce disease.

Last updated on 05-01-20

How can Fox-Fordyce disease be managed in the long-term?

Fox-Fordyce disease is a chronic condition. Once relief has been achieved, long-term, low-dose therapy is recommended. Individuals with Fox-Fordyce disease should avoid activities that can lead to sweating.

Last updated on 05-01-20

How might Fox-Fordyce disease be treated?

Individuals with Fox-Fordyce disease should consult with a dermatologist regarding treatment. Some of the recent treatments for the FFD include: interlesional glucocorticoids, topical steroids, oral and topical retinoids, topical clindamycin, topical pimecrolimus cream, benzoyl peroxide, oral antibiotics and contraceptives or antiandrogenic hormonal therapy. Pimecrolimus and tacrolimus, both with significant anti-inflammatory activity and low side-effects, have provided rapid improvement in a limited number of cases. Other forms of treatment used are ultraviolet radiation (phototherapy), dermabrasion, liposuction and surgical excision. Immunosuppressants have been utilized with modest success. For individuals who do not respond to medications, destruction or removal of the apocrine sweat glands (glands that surround hair follicles) has been effective in some cases.

Last updated on 05-01-20

Yost, J., Robinson, M., & Meehan, S. A. Fox-Fordyce disease Dermatology online journal. 2012; 18(12). Reference Link Yost, J., Robinson, M., & Meehan, S. A. Fox-Fordyce disease Dermatology online journal. 2012; 18(12). Reference Link

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