Adie syndrome

What causes Adie syndrome?

In most cases, the cause of Adie syndrome is unknown (idiopathic). The tonic pupil in Adie syndrome is believed to result from inflammation or damage to the ciliary ganglion (a cluster of nerve cells found behind the eye) or damage to the post-ganglionic nerves. The ciliary ganglion is part of the parasympathetic nervous system, a component of the autonomic nervous system. It helps control the pupil's response to light and other stimuli. In most cases, damage to the ciliary ganglion or post- ganglionic nerves is caused by an infection. Damage may also result from autoimmune processes, tumors, trauma, and complications of surgery.

The loss of deep tendon reflexes in Adie syndrome is believed to be caused by damage to the dorsal root ganglion, a cluster of nerve cells in the root of the spinal nerves.

In rare cases, Adie syndrome may be inherited. In these cases, it appears to follow an autosomal dominant pattern of inheritance.

Last updated on 05-01-20

How might Adie syndrome be treated?

Doctors may prescribe reading glasses to compensate for impaired vision in the affected eye, and pilocarpine drops to be applied 3 times daily to constrict the dilated pupil. This may help with depth perception and reduce glare. For many, these strategies improve vision. Thoracic sympathectomy, which severs the involved sympathetic nerve, is the definitive treatment for excessive sweating.

Last updated on 05-01-20

Name: American Autonomic Society 18915 Inca Ave
Lakeville, MN, 55044,
Phone: 952-469-5837 Email: Url:
Name: European Federation of Autonomic Nervous System Societies Via Ugo Foscolo, 7
Bologna, 40123, Italy
Phone: +390512092929 Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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