Eosinophilic fasciitis

How might eosinophilic fasciitis be treated?

About 10-20% of people with eosinophilic fasciitis recover spontaneously without treatment. For those who do not, glucocorticoids (0.5–1 mg/kg/d), such as prednisone, are the mainstay therapy. Even with treatment, improvement in symptoms can take weeks or months. Glucocorticoids are successful in treating eosionophilic fasciitis in over 70% of cases. If glucocorticoids are unsuccessful, methotrexate at low doses (15–25 mg once weekly) is probably the most favored second-line treatment, especially in people with reddish to purpleish (morphea-like) skin lesions. Other treatment options include NSAIDs, D-penicillamine, chloroquine, cimetidine, azathioprine, cyclosporin A, infliximab, UVA-1, and bath PUVA. Physical therapy may help improve joint mobility and decrease contractures. Surgical release has been used in some severe cases to manage significant joint contractures.

Last updated on 05-01-20

Selected Full-Text Journal Articles

Journal articles Eosinophilic fasciitis

Last updated on 04-27-20

Name: American Partnership For Eosinophilic Disorders PO Box 29545
Atlanta, GA, 30359, United States
Phone: 713-493-7749 Email: mail@apfed.org Url: http://www.apfed.org
Name: International Eosinophil Society 555 East Wells Street, Suite 1100
Milwaukee, WI, 53202, United States
Phone: 414-276-6445 Email: info@eosinophil-society.org/ Url: http://www.eosinophil-society.org/
Name: American Autoimmune Related Diseases Association (AARDA) 22100 Gratiot Avenue
Eastpointe, MI, 48021, United States
Phone: 586-776-3900 Toll Free: 800-598-4668 Fax : 586-776-3903 Email: aarda@aarda.org Url: https://www.aarda.org/

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