Can dysfibrinogenemia go away as a person ages?

Congenital dysfibrinogenemia, the inherited form caused by mutations in specific genes, is present from birth and throughout life, even though a person may not have symptoms.

Acquired dysfibrinogenemia may be due to a number of conditions, including liver disease (such as cirrhosis, hepatitis, or liver tumors); renal carcinoma (kidney cancer); isotretinoin therapy; and biliary obstruction. In these cases, the abnormal fibrinogen may disappear with treatment of the underlying condition, or may disappear spontaneously (on its own).

Last updated on 05-01-20

How many people have dysfibrinogenemia?

Congenital dysfibrinogenemia is considered rare, but the true incidence is unknown since many forms don't cause signs or symptoms. In the literature, only 200-300 families have been reported.

Approximately 50% of patients with severe liver disease have bleeding tendencies secondary to abnormal fibrinogen (acquired dysfibrinogenemia).

Last updated on 05-01-20

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