Acute posterior multifocal placoid pigment epitheliopathy

Is the vision loss associated with acute posterior multifocal placoid pigment epitheliopathy permanent?

In most instances, the disorder resolves within a few weeks with return to prior sharpness of vision (acuity). In a small number of individuals, permanent visual loss may occur due to the creation of new blood vessels in the eye (subretinal neovascularization). Other people may have long-term symptoms such as a partial loss of vision or blind spot (scotomata) or distorted vision (metamorphopsia).

Last updated on 05-01-20

Has memory loss been reported in people with acute posterior multifocal placoid pigment epitheliopathy (APMPPE)?

While we are not aware of the specific symptom of memory loss being reported in people with APMPPE, the association between APMPPE and central nervous system (CNS) complications is well known. There have been reports of various neurological signs and symptoms in people with APMPPE including headaches (the most common symptom); confusion; hemiplegia; hemiparesis; dysarthria; numbness; ataxia; incontinence; hearing loss; optic neuritis; meningoencephalitis; transient ischemic attacks; and strokes. Cerebrovascular lesions (abnormalities in the blood vessels supplying the brain) in people with APMPPE have been documented, and cerebral vasculitis associated with APMPPE has been reported to cause permanent and severe neurological complications in some cases.

If there is suspected neurological involvement in a person with APMPPE, MRI and lumbar puncture (spinal tap) may be used to identify CNS involvement. If CNS involvement is found, treatment should begin immediately. People with APMPPE who are concerned about neurological signs or symptoms should speak with their health care provider promptly and consult with a neurologist and/or a neurovascular specialist.

Last updated on 05-01-20

Do the deposits associated with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) damage the macula?

There have been few reports about the long-term effects of APMPPE on macular function. It has been suggested that the prognosis relating to macular function may be good, unless lesions in the retina or retinal pigment epithelium persist. Because not all people with APMPPE are affected the same way, those who have specific questions about their own prognosis should speak with their ophthalmologist.

Last updated on 05-01-20

What is the long-term outlook for people with acute posterior multifocal placoid pigment epitheliopathy (APMPPE)?

In many affected people, visual acuity returns to the range of 20/20 to 20/40. However, some people have permanent vision loss or long-term functional ocular symptoms. Other ocular and non-ocular symptoms usually resolve on their own and are not life-threatening. In affected people with cerebral vasculitis, there can be permanent and/or severe neurological complications; there have been instances of death following an episode of cerebral vasculitis.

Last updated on 05-01-20

How might acute posterior multifocal placoid pigment epitheliopathy (APMPPE) be treated?

The treatment of APMPPE is somewhat controversial, but the general consensus is that no treatment seems to alter the course of the ocular lesions. In cases complicated by subretinal neovascularization (growth of new blood vessels), laser photocoagulation may be useful.

In most cases, the lesions resolve spontaneously and no therapy is required. Some clinicians have used corticosteroids (which suppress inflammation) to treat the ocular findings and any severe systemic involvement. However, there is no evidence that treatment with corticosteroids affects the visual outcome. The use of steroids has also been suggested when treating cases where the macula is involved. Cycloplegics may be useful for severe iritis, which is an uncommon finding.

It is recommended that people with questions about treatment options for themselves or family members speak with their health care provider.

Last updated on 05-01-20

Name: American Uveitis Society PO Box 016880
Miami, FL, 33101-6880, United States
Phone: 305-326-6377 Fax : 305-326-6071 Url:
Name: Ocular Immunology and Uveitis Foundation 348 Glen Road
Weston, MA, 02493, United States
Phone: +1-781-647-1431 Email:; (support) Url:

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