Disseminated peritoneal leiomyomatosis

What causes disseminated peritoneal leiomyomatosis (DPL)?

The cause of disseminated peritoneal leiomyomatosis (DPL) is unknown, but medical researchers believe it is influenced by both hormonal and genetic factors. Not all cases are related to hormone levels, as some cases have occurred in men and in post- menopausal women not receiving hormone replacement therapy. DPL is often associated with uterine leiomyomas but the connection is unclear.

Most cases occur sporadically in people with no family history of the condition; however, more than one family member can be affected. Although this suggests that genetic factors may play a role in the development of DPL in some families, researchers have not identified any specific gene changes known to cause the condition.The cause of the condition is considered multifactorial .

Last updated on 05-01-20

How is disseminated peritoneal leiomyomatosis (DPL) diagnosed?

An ultrasound may reveal the presence of nodules (lumps) which may indicate disseminated peritoneal leiomyomatosis (DPL). However, DPL can only be confirmed by a biopsy of the nodule. The nodules should contain smooth muscle cells with no atypia (no abnormal structure) or necrosis (dead cells). The cells usually have both progesterone and estrogen receptors, but this is not always the case. The cells usually have a low mitotic index (meaning they are not dividing at a high rate).

Last updated on 05-01-20

How might disseminated peritoneal leiomyomatosis (DPL) be treated?

Presently there are no treatment guidelines for disseminated peritoneal leiomyomatosis (DPL). DPL is considered a benign condition and some cases of DPL resolve after the baby is delivered (if pregnant), hormone treatment is stopped (including both birth control pill and hormone replacement therapy), or a hormone producing tumor is removed. However, surgery may be suggested based on the size and location of the tumor.

Last updated on 05-01-20

Zyla MM. Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report Acta Obstet Gynecol Scand. February, 2015; 94(2). 220-3. Reference Link Momtahan M, Nemati M & Safaei A. Disseminated Peritoneal Leiomyomatosis Iran J Med Sci. March, 2011; 36(1). 57–59. Reference Link

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