Acute myelomonocytic leukemia
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The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.
Orpha Number: 517
Definition
A rare acute myeloid leukemia disorder characterized by increased blast cells (myeloblasts, monoblast, and/or promonoblasts), representing more than 20% of the total bone marrow (BM) or peripheral blood differential counts, with 20-80% of BM cells being of monocytic lineage. Clinical presentation is the result of bone marrow involvement and extramedullary infiltration by the leukemic cells and includes asthenia, pallor, fever, dizziness, respiratory symptoms, easy bruising, bleeding disorders, and neurological deficits. Gingival hyperplasia, organomegaly, especially hepatosplenomegaly, and lymphadenopathy may also be associated.
Visit the Orphanet disease page for more resources.
Source: GARD Last updated on 05-01-20
Symptoms
Symptoms and their Known Frequencies
80%-99% of people have these symptoms.
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| Anemia |
| Increased bone mineral density |
| Thrombocytopenia |
30%-79% of people have these symptoms.
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| Pica |
| Recurrent opportunistic infections |
| Abnormal bleeding |
| Dyspnea |
| Pallor |
| Weight loss |
5%-29% of people have these symptoms.
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| Abnormality of T cell physiology |
| Nodular goiter |
| Abnormality of the gingiva |
| Eosinophilia |
An unknown % of people have these symptoms.
Click on a symptom to see definitions for associated terms.
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