Diffuse gastric cancer

Can diffuse gastric cancer be inherited?

Diffuse gastric cancer can be inherited or can happen sporadically in a family. Sporadic means that the cancer occurred randomly for the first time in a individual and was not inherited from a parent. Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the CDH1 gene. Individuals with a CDH1 mutation typically develop cancer before age 40.

Last updated on 05-01-20

What is hereditary diffuse gastric cancer?

Hereditary diffuse gastric cancer (HDGC) is an inherited condition that is characterized by an increased risk of developing a specific form of stomach cancer called diffuse gastric cancer. Women with HDGC also have an increased risk for lobular breast cancer. Cancers associated with HDGC generally occur at younger ages than those seen in people who do not have a hereditary predisposition to cancer. HDGC is caused by changes (mutations) in the CDH1 gene and is inherited in an autosomal dominant manner. Management typically involves high-risk cancer screening and/or prophylactic surgeries.

Last updated on 05-01-20

Can diffuse gastric cancer be caused by excessive drinking?

Most of the time the exact cause of gastric cancer can not be determined; however there are many different factors that may put someone at an increased risk for developing stomach cancer. While it isn't clear if alcohol alone can increase this risk, it is thought that regular drinking may increase the risk in smokers.

You can visit the following information pages develped by the National Cancer Insitute and Cancer Research UK to learn more about these risks.
http://www.cancer.gov/cancertopics/wyntk/stomach/page4
http://www.cancerhelp.org.uk/help/default.asp?page=3903

Last updated on 05-01-20

Name: American Cancer Society 250 Williams Street NW
Atlanta, GA, 30329, United States
Toll Free: 1-800-227-2345 Url: https://www.cancer.org
Name: Cancer Hope Network 2 North Road, Suite A
Chester, NJ, 07930, United States
Phone: +1-908-879-4039 Toll Free: 1-877-467-3638 (1-877-HOPENET) Fax : +1-908-879-6518 Email: info@cancerhopenetwork.org/ Url: https://www.cancerhopenetwork.org/
Name: AMC Cancer Research Center 3401 Quebec St, Suite 3200
Denver, CO, 80207, United States
Phone: 303-233-6501 Toll Free: 800-321-1557 Fax : 303-239-3400 Email: contactus@amc.org Url: http://www.amc.org/
Name: No Stomach For Cancer 9202 Waterside Street, #203
Middleton, WI, 53562, United States
Phone: 608-335-0241 Email: info@nostomachforcancer.org Url: http://www.nostomachforcancer.org/

Note, these links are external searches against the National Laboratory of Medicine's drug database. You may need to adjust the search if there are no results found.

Drug Name Generic Name
Lonsurf trifluridine/tipiracil

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