Cryptogenic organizing pneumonia

What causes cryptogenic organizing pneumonia?

The underlying cause of cryptogenic organizing pneumonia (COP) is unknown (idiopathic). Organizing pneumonia is specifically diagnosed as COP when, among other characteristics, no definite cause for the organizing pneumonia is found. In other words, any known cause for the pneumonia must be ruled out before stating that a person is affected by COP.

Other forms of organizing pneumonia may result from infection (bacteria, viruses, parasites, or fungi); drugs; or a reaction to radiation therapy for breast cancer. Organizing pneumonia can also be associated with specific disorders such as certain connective tissue disorders, blood malignancies (cancers), or ulcerative colitis.

Last updated on 05-01-20

How is cryptogenic organizing pneumonia diagnosed?

A diagnosis of cryptogenic organizing pneumonia is often suspected based on the presence of characteristic signs and symptoms once other conditions that cause similar features have been excluded. This includes ruling out other known causes of organizing pneumonia. Additional testing such as a computed tomography (CT) scan or lung biopsy can confirm the diagnosis.

Last updated on 05-01-20

Is cryptogenic organizing pneumonia inherited?

We are not aware of any familial cases of cryptogenic organizing pneumonia (COP) in the medical literature, and to our knowledge, there is no evidence that some people may be genetically predisposed to developing COP.

Last updated on 05-01-20

What is the long-term outlook for people with cryptogenic organizing pneumonia?

The long-term outlook (prognosis) for people with cryptogenic organizing pneumonia (COP) is generally good. Approximately two-thirds of affected people recover after treatment with glucocorticoids. Unfortunately, a third of affected people experience persistent symptoms and/or abnormalities on pulmonary function testing. Rapidly fatal COP is uncommon.

Last updated on 05-01-20

How might cryptogenic organizing pneumonia be treated?

The treatment of cryptogenic organizing pneumonia (COP) generally depends on the severity of the condition. For example, people who are mildly affected may simply be monitored as some cases can improve on their own. Unfortunately, the majority of people with COP have persistent and/or progressive symptoms that will require therapy. In these cases, oral or intravenous glucocorticoids can be given which often result in rapid improvement of symptoms.

Last updated on 05-01-20

Name: American Lung Association 55 W. Wacker Drive, Suite 1150
Chicago, IL, 60601, United States
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Name: Children's Interstitial Lung Disease Foundation 6539 Harrison Ave #1045
Cincinnati, OH, 45247, United States
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