What causes craniorachischisis?

Despite neural tube defects (NTDs) being among the most common birth defects, their underlying cause is not completely understood. In most cases they are thought to be multifactorial, which means that one or more genes interact with the environment to predispose an individual to having a NTD. Because folic acid can sometimes prevent NTDs, many studies have focused on genes known to be involved in folate metabolism. In some populations, the MTHFR gene has been associated with NTDs. More recent studies have suggested that mutations in the CELSR1 and SCRIB genes may be associated with craniorachischisis specifically.

Last updated on 05-01-20

Name: Spina Bifida Association 4590 MacArthur Boulevard, NW
Washington , DC, 20007, United States
Phone: 202-944-3285 Toll Free: 800-621-3141 Fax : 202-944-3295 Email: Url:
Name: March of Dimes 1275 Mamaroneck Avenue
White Plains, NY, 10605, United States
Phone: 914-997-4488 Toll Free: 888-663-4637 Fax : 914-997-4763 Email: Url:

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