Corticobasal degeneration

What causes corticobasal degeneration?

The underlying cause of corticobasal degeneration (CBD) is poorly understood. However, researchers have found that a protein called tau plays a role in the development of CBD. Tau is a specific type of protein that is normally found in the brain. In CBD, abnormal levels of tau accumulate in the brain cells, eventually leading to their deterioration and causing symptoms of the condition. Exactly why this happens is unknown. Tau also appears to play a role in other neurodegenerative diseases such as Alzheimer disease, progressive supranuclear palsy, and frontotemporal dementia. There is no evidence to suggest that environmental exposure to toxic or infectious agents plays a role in causing CBD.

Last updated on 05-01-20

Is corticobasal degeneration inherited?

Corticobasal degeneration (CBD) is almost always sporadic, developing by chance rather than being inherited. Rare familial cases have been reported, leading to the possibility that there may be a genetic basis for at least a predisposition to CBD. Some research has found associations with CBD and a specific form (variant) of the tau gene. However, not all people with CBD have the tau gene variant, and not all people with the gene variant develop CBD.

Last updated on 05-01-20

Where To Start

Corticobasal degeneration

The University of California San Francisco Web site has an information page on this topic. Click on the link above to view the information page.

Last updated on 04-27-20

Name: CurePSP 1216 Broadway, 2nd Floor
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Phone: +1-347-294-2873 (CURE) Toll Free: 1-800-457-4777 Fax : +1-410-785-7009 Email: info@curepsp.org Url: https://www.psp.org/
Name: Frontotemporal Dementia Caregiver Support Center Email: jeffbrauer@cableone.net Url: http://www.ftdsupport.com
Name: International Parkinson and Movement Disorder Society 555 East Wells Street, Suite 1100
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Phone: +1-414-276-2145 Fax : +1-414-276-3349 Email: info@movementdisorders.org Url: https://www.movementdisorders.org/
Name: Association for Frontotemporal Degeneration AFTD Radnor Station Building 2 Suite 320
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Radnor, PA, 19087, United States
Phone: +1-267-514-7221 Toll Free: 1-866-507-7222 Email: info@theaftd.org Url: https://www.theaftd.org/
Name: CBD Solutions Email: http://www.cbdsolutions.se/contact.html Url: http://www.cbdsolutions.se/

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