Congenital chloride diarrhea

How might congenital chloride diarrhea be treated?

Congenital chloride diarrhea (CCD) is a lifelong disease, so treatment focuses on managing symptoms and preventing complications. Early diagnosis and treatment in the absence of major complications can lead to normal growth and development. The main treatment is called salt substitution therapy (receiving sodium chloride and potassium chloride). Newborns are first given this therapy intravenously (by IV) and are later transitioned to oral therapy. Diarrhea will persist through therapy even when there is adequate salt substitution, although the relative amount of stool generally decreases with age.

Treatment for episodes of acute gastroenteritis ("stomach flu") in children with CCD is extremely important because they can experience rapid dehydration and loss of potassium (hypokalemia). These episodes should be treated with IV replacement of fluids and electrolytes. In adulthood, people with CCD are usually able to avoid dehydration by taking extra salt substitution.

Last updated on 05-01-20

Selected Full-Text Journal Articles

Article - Congenital Chloride Losing Diarrhea

Alzahrani AK. Congenital Chloride Losing Diarrhea. Pediat Therapeut 2014, 4:2.

Last updated on 04-27-20

Name: American Gastroenterological Association 4930 Del Ray Avenue
Bethesda, MD, 20814, United States
Phone: 301–654–2055 Fax : 301–654–5920 Email: Url:
Name: International Foundation for Functional Gastrointestinal Disorders IFFGD PO Box 170864
Milwaukee, WI, 53217, United States
Phone: +1-414-964-1799 Toll Free: 1-888-964-2001 Fax : +1-414-964-7176 Email: Url:
Name: Association of Gastrointestinal Motility Disorders AGMD Bedford, MA, 01730, United States Phone: +1-781-275-1300 Email: Url:

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