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Don’t fight Clouston syndrome alone.
Find your community on the free RareGuru App.Clouston syndrome is a form of ectodermal dysplasia that is characterized by abnormalities of the skin, hair and nails. Early signs and symptoms generally begin in infancy and may include nail abnormalities and sparse scalp hair that is wiry, brittle, patchy and pale. Progressive hair loss may lead to total alopecia by puberty. Affected people may also have palmoplantar hyperkeratosis (thick skin on the palms of the hands and soles of the feet), hyperpigmentation of skin (especially over joints) and/or clubbing of the fingers. Clouston syndrome is caused by changes (mutations) in the GJB6 gene and is inherited in an autosomal dominant manner. Treatment is based on the signs and symptoms present in each person.
Source: GARD Last updated on 05-01-20
80%-99% of people have these symptoms.
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30%-79% of people have these symptoms.
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| Fine hair |
| Palmoplantar keratoderma |
| Hypotrichosis |
| Cataract |
| Round ear |
| Short stature |
| Nuclear pulverulent cataract |
| Achlorhydria |
| Sparse eyelashes |
| Photophobia |
| Skin ulcer |
| Sparse and thin eyebrow |
5%-29% of people have these symptoms.
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An unknown % of people have these symptoms.
Click on a symptom to see definitions for associated terms.
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