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Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone condition. Signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. Symptoms typically begin in childhood. CRMO may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, Majeed syndrome or DIRA. For most children, CRMO resolves after many years without lasting effects. However, CRMO can cause slow growth and permanent bone deformity.
Source: GARD Last updated on 05-01-20
Due to the rare nature of the condition, there is limited data regarding the best treatment approach for people with chronic recurrent multifocal osteomyelitis (CRMO). When CRMO occurs along with psoriasis or inflammatory bowel disease the goal is to treat both the CRMO as well as the skin and gastrointestinal symptoms. In this situation, treatment with a TNF inhibitor may be recommended. Initial treatment of isolated CRMO often involves NSAIDs. If NSAIDs are unable to control pain, additional treatment options include antirheumatic drugs (e.g., corticosteroids, methotrexate, sulfasalazine, colchicine, and azithromycin), TNF inhibitors, or bisphosphonates.
Last updated on 05-01-20
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