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Chromosome 10p duplication is a chromosome abnormality that occurs when there is an extra copy of genetic material on the short arm (p) of chromosome 10. The severity and the signs and symptoms depend on the size and location of the duplication and which genes are involved. The size of the duplication can range from a tiny piece of the chromosome arm, to the entire arm. Signs and symptoms that can be present in a person with a 10p duplication may include delay of development, motor skills, or growth; short stature; low muscle tone (hypotonia); abnormalities of the foot (such as clubfoot); cleft lip and/or cleft palate; and distinctive facial features. Other signs and symptoms may include seizures, a heart defect, or other birth defects.
Some 10p duplications are not inherited and occur sporadically (randomly) when egg or sperm cells form, or shortly after the egg and sperm join together. In other cases, the duplication occurs because a parent has a chromosome rearrangement such as a balanced translocation or a pericentric inversion (neither of which usually causes health problems). A chromosome test of both parents can help determine whether the duplication was inherited, and whether future children have an increased chance to have a chromosome abnormality. Treatment is based on the signs and symptoms present in each person.
This page is meant to provide general information about 10p duplications. You can contact GARD if you have questions about a specific duplication on chromosome 10. To learn more about chromosomal anomalies please visit our GARD webpage on FAQs about Chromosome Disorders.
Source: GARD Last updated on 05-01-20
Unique is a source of information and support to families and individuals affected by rare chromosome disorders. Click on the link to view information about duplications of 10p.
Last updated on 04-27-20
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