Chandler's syndrome

What causes Chandler's syndrome?

The underlying cause of Chandler's syndrome is unknown. Some researchers suspect that inflammation or chronic viral infection may play a role in the development of this condition.

Chandler's syndrome develops when the endothelium, the single layer of cells lining the inside of the surface of the cornea, fails to pump the aqueous humor from the cornea. This allows fluid to accumulate in the cornea (corneal edema), leading to blurred vision.

Last updated on 05-01-20

Is Chandler's syndrome inherited?

While the cause of Chandler's syndrome is unknown, at this time there is no evidence that it is inherited (hereditary).

Last updated on 05-01-20

What is Chandler's syndrome?

Chandler's syndrome is a rare eye disorder in which the single layer of cells lining the interior of the cornea proliferates, causing changes within the iris, corneal swelling, and unusually high pressure in the eye (glaucoma). This condition is one of three syndromes, along with progressive iris atrophy and Cogan-Reese syndrome, that make up the iridocorneal endothelial (ICE) syndrome. In most cases, only one eye is affected. Symptoms may include reduced vision and pain. Chandler's syndrome more often affects females and usually presents sometime during middle age. The cause of this disease is unknown.

Last updated on 05-01-20

If one eye is affected by Chandler's syndrome, is it possible for the other to become involved?

Most often, Chandler's syndrome affects only one eye. The other eye may have subclinical involvement (below the level required for diagnosis). In rare cases, both eyes may be clinically involved.

Last updated on 05-01-20

How might Chandler's syndrome be treated?

While it is not possible to halt the progression of Chandler's syndrome, the glaucoma associated with this disease can be treated with medications and/or filtering surgery. Eye drops used in managing glaucoma decrease pressure in the eye by helping the eye's fluid drain more efficiently and/or decreasing the amount of fluid made by the eye. Drugs used to treat glaucoma are classified according to their active ingredient. These include prostaglandin analogs, beta blockers, alpha agonists, and carbonic anhydrase inhibitors. Combination drugs may be necessary for some patients. If these medications do not successfully treat the glaucoma, surgery may be indicated. Trabeculectomy may be used to treat glaucoma. In some cases, multiple procedures may be necessary. The corneal swelling associated with Chandler's syndrome may be treated through a cornea transplant. Further investigation is needed to determine the best way to manage this condition.

Last updated on 05-01-20

Can Chandler's syndrome be treated with existing laser technology?

No. Existing laser therapy has not proven to be an effective treatment for Chandler's syndrome.

Last updated on 05-01-20

Name: Glaucoma Research Foundation 251 Post Street, Suite 600
San Francisco, CA, 94108, United States
Phone: 415-986-3162 Toll Free: 800-826-6693 Fax : 415-986-3763 Email: Url:
Name: Cornea Research Foundation of America 9002 N. Meridian Street, Suite 212
Indianapolis, IN, 46260, United States
Phone: 317-844-5610 Fax : 317-814-2806 Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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